I was born on Christmas Day...was a sickly boy brought up by my grandmother and a maternal uncle.

My first mathematical discovery at age 22 was the expression of functions in terms of infinite series.

When Trinity College closed due to the plague, I was forced to stay at home...and thought and thought...and played with alchemy.

While restricted to my home, I generalized the binomial theorem to rational powers, discovered the principles of calculus, derived the law of gravitation, and explored the nature of colors.

In 1675, I suffered a mental breakdown that lasted four years...during which I produced a theory for planetary orbits.

Throughout my scientific career. I was extremely sensitive to criticism and became quite eccentric in my late life.