Blinded by small pox at age one (and losing both eyes), I taught myself to read by using my fingers to trace letters on gravestones.
To compensate for my blindness as a youth, I invented abacus-like counting boards and the modern geoboard in order to do arithmetic and geometry.
Despite this apparent handicap in a visual field, I eventually was elected to the prestigious Lucasian Chair...earlier held by both Newton and Isaac Barrow.
Though not supported professionally by Newton, I spread his ideas (especially on optics) through my lectures and published course materials.
I did little if any new research, focusing instead on my teaching of mathematics, which included lecturing and tutoring students for 8+ hours each day.
One of my former students said that I "did not have the use of [my] eyes, but taught others to use theirs."
Nicholas Saunderson (1682 - 1739)